MBSeq: Single cell/nuclei DNA- and RNA-seq of LFS Medulloblastoma samples

Processed Data accompanying the manuscript:

Multi-omic and single-cell profiling of chromothriptic medulloblastoma reveals genomic and transcriptomic consequences of genome instability

Petr Smirnov 1,2, Moritz J. Przybilla 2,3,4, Milena Simovic-Lorenz 1, R. Gonzalo Parra 2,3,5, Hana Susak 2,3, Manasi Ratnaparkhe 1, John KL. Wong 6, Verena Körber7, Jan-Philipp Mallm8, George Philippos 1,9, Martin Sill 10,11, Thorsten Kolb 1, Rithu Kumar 1, Nicola Casiraghi 2,3, Konstantin Okonechnikov 10,11, David R. Ghasemi 10,11,12, Kendra Korinna Maaß 10,11,12, Kristian W. Pajtler 10,11,12, Anna Jauch 13, Andrey Korshunov 14, Thomas Höfer 7, Marc Zapatka 6, Stefan M. Pfister 10,11,12, Wolfgang Huber 2, Oliver Stegle #2,3,4, Aurélie Ernst* #1

1 Group Genome Instability in Tumors, German Cancer Research Center (DKFZ), and German Cancer Consortium (DKTK), Heidelberg, Germany. 

2 European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany

3 Division of Computational Genomics and Systems Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany

4 Wellcome Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK

5 Life Sciences Department, Barcelona Supercomputing Center, Barcelona, Spain

6 Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany

7 Division of Theoretical Systems Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany

8 Single-cell Open Lab, German Cancer Research Center (DKFZ) and Bioquant, Heidelberg, Germany

9 Faculty of Biosciences, Heidelberg University, Heidelberg, Germany

10 Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany. 

11 Division of Pediatric Neuro-oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany. 

12 Department of Pediatric Oncology, Hematology, and Immunology, Heidelberg University Hospital, Heidelberg, Germany.

13 Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany

14 Clinical Cooperation Unit Neuropathology, DKFZ, Department of Neuropathology, Heidelberg University Hospital 

NOTE: 

During manuscript preperation, the sample names were changed to coincide better with other published papers on these samples. The following translation applied between sample names used in the manuscript and in the datasets accompanying the paper:

STP-Nuclei/PDX = LFS MBP Nuclei / PDX

ST1R-Nuclei/PDX = LFS MB1R Nuclei / PDX

MB243 = MB243

BT084 = BT084

RCMB18 = RCMB18