Supporting data for thesis entitled "Soluble CUB Domain-containing Protein 1 promotes dysfunction-associated steatohepatitis through recruitment and activation of intrahepatic macrophages"

This dataset contains proteomics data supporting the thesis entitled "Soluble CUB Domain-containing Protein 1 promotes dysfunction-associated steatohepatitis through recruitment and activation of intrahepatic macrophages".Metabolic dysfunction-associated steatotic liver disease (MASLD), formly named non-alcoholic fatty liver disease, affects over 30% of the general population and 76% of obese individuals worldwide, making it the most prevalent chronic liver disease. Its advanced stage, metabolic dysfunction-associated steatohepatitis (MASH), is characterized by hepatic ballooning and lobular inflammation, posing a significant risk of progressing to fibrosis, cirrhosis, and hepatocarcinoma. MASH often coexists with a cluster of cardiometabolic diseases and has become the primary reason for liver transplantation. Consequently, there is an urgent need for effective strategies for non-invasive diagnosis and therapeutic intervention for MASH and its associated comorbidities. To address this pressing issue, we assembled a substantial cohort with liver biopsy and histological diagnosis and amassed a wealth of clinical and preclinical evidence pointing to secreted form of CDCP1 (sCDCP1) as a crucial mediator of MASH. Our findings hold the potential to facilitate the clinical implementation of circulating sCDCP1 as a pathogenic biomarker for the non-invasive diagnosis and precise management of MASH.