Amino acid sequences of α-gliadin derived peptides.

Five antigenic peptides derived from α-gliadins are known to be involved in celiac decease. For the peptides that can provoke an adaptive immune response in CD patients (HLA-DQ2 restricted or HLA-DQ8 restricted) the minimal 9-mer “canonical” epitope cores are shown. One peptide, p31-43, is known to be involved in an innate immune response observed in CD. For each of the epitopes is specified the name, which immune response it evokes, the restriction element and the amino acid sequence.