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Thermodynamic analysis in silico of missense variants in MEN1

Figshare2019-09-12 更新2026-04-08 收录

变异致病性预测

蛋白质稳定性

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https://figshare.com/articles/Thermodynamic_analysis_in_silico_of_missense_variants_in_MEN1/9810500/1 数据链接链接失效反馈

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资源简介：

Dataset for thermodynamic analysis in silico of 338 previously-reported missense variants in MEN1

应用场景：

创建时间：

2019-09-12

蛋白质稳定性

计算生物学

Design of proteins with desired thermal properties is important for scientific and biotechnological applications. Here we developed a theoretical approach to predict the effect of mutations on protein

NIAID Data Ecosystem60

CONTRIBUTION OF HYDROPHOBIC RESIDUES TO THE STABILITY OF HUMAN LYSOZYME: X-RAY STRUCTURE OF THE V74A MUTANT

蛋白质稳定性

X射线晶体学

CONTRIBUTION OF HYDROPHOBIC RESIDUES TO THE STABILITY OF HUMAN LYSOZYME: X-RAY STRUCTURE OF THE V74A MUTANT Descriptor: LYSOZYME, SODIUM ION Authors: Takano, K, Yamagata, Y, Fujii, S, Yutani, K. Depos

Protein Data Bank Japan2024-11-06 更新30

Comparative Analysis of Protein Folding Stability-Based Profiling Methods for Characterization of Biological Phenotypes

蛋白质稳定性

生化表征

Recently, a new suite of mass spectrometry-based proteomic methods has been developed that enables evaluation of protein folding stability on the proteomic scale. These methods utilize chemical and th

NIAID Data Ecosystem10

Increase in the thermostability of Bacillus sp. strain TAR-1 xylanase using a site saturation mutagenesis library

酶工程

蛋白质稳定性

Site saturation mutagenesis library is a recently developed technique, in which any one out of all amino acid residues in a target region is substituted into other 19 amino acid residues. In this stud

NIAID Data Ecosystem40

Number of clusters (NOC) at 1.15 Å RMSD cutoff for the MD simulations and experimental thermodynamic stability data for wild-type p53 and its more-stabilized forms.

蛋白质稳定性

分子动力学模拟

aRef 23. bRef 37. Both mutants are functionally active.

NIAID Data Ecosystem20