Anti-microRNA-21 therapy on top of ACE-inhibition delays renal failure in Alport syndrome mouse models
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE179938
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The goal of this study was to compare Next Generation mRNA (RNA-seq) data obtained from whole kidney tissue from WT and untreated, Lademirsen treated and Ramipril treated Col4a3-/- mice in the mixed 129/SvJ and B57BL/6J background Comparison in WT vs Col4a3-/- Vehicle, Col4a3-/- Vehicle vs Ramipril, and Col4a3-/- Vehicle vs Lademirsen kidneys of RNA expression of 10 most altered canonical pathways and more specifically "Renal Tubulointerstitial Injury in Lupus Nephritis" and "Mitochondrial Dysfunction in Neurodegenerative Diseases" .
创建时间：
2022-05-06
