Appendices: Real-world treatment, clinical outcomes and healthcare resource utilization among persons with hemophilia A by age

<b>These are peer-reviewed appendices for the article '</b><b>Real-world treatment, clinical outcomes and healthcare resource utilization among persons with hemophilia A by age</b><b>' published in the </b><b><i>Journal of Comparative Effectiveness Research.</i></b>Appendix A. NDC, GPI, and HCPCS Codes for Hemophilia-related Therapies.Appendix B. ICD-9/10 and CPT Codes for Hemophilia-related Diagnoses and Events.Appendix C. Exclusions.Appendix D. LOINC Codes.Appendix E. ICD-9/10 Procedure and CPT Codes for Joint Procedures and Surgery.Appendix F. Fracture Codes.<b>Summary: </b><b>Aim</b>:<b> </b>Examine real-world characteristics, treatment patterns, and outcomes among treated persons with hemophilia A (PwHA) stratified by age. <b>Patients &amp; methods</b>: This study utilized US claims data from 1 January 2007–31 July 2018 from the Humana Research Database. Unadjusted comparisons were conducted across PwHA (&lt;18, 18–55, 56–89 years) enrolled in commercial or Medicare Advantage Prescription Drug plans. <b>Results</b>: A total of 294 PwHA were identified; 21.1% experienced ≥1 bleeding event, and 41.2 and 53.1% had evidence of arthropathy or related disorders, and pain, respectively. Along with all-cause and hemophilia-related healthcare resource utilization (HCRU), these were highest among PwHA aged 56–89 years. <b>Conclusion</b>: Insights into treatment, outcomes and HCRU may identify opportunities for enhanced disease management, particularly in older PwHA.