X-ray structure of human PPARalpha ligand binding domain-10-hydroxystearic acid (10-HSA) co-crystals obtained by cross-seeding

X-ray structure of human PPARalpha ligand binding domain-10-hydroxystearic acid (10-HSA) co-crystals obtained by cross-seeding Descriptor: (10R)-10-hydroxyoctadecanoic acid, GLYCEROL, Peroxisome proliferator-activated receptor alpha Authors: Liu, J, Krause, H.M, Kamata, S, Honda, A, Watase, K, Ishii, I. Deposit date: 2025-07-23 Release date: 2026-05-27 Last modified: 2026-08-12 Method: X-RAY DIFFRACTION (1.455 Å) Cite: Microbial 10-oxostearic acid protects mice against colitis via the nuclear receptor PPAR alpha. Nat Microbiol, 11, 2026