Hazard ratios (HR) * and 95% confidence intervals (CI) for a methylation index † according to anthropometric risk factors and physical activity in the NLCS 7.3 years of follow-up.

*All models were adjusted for age and sex. Models with BMI and BMI at age 20 were additionally adjusted for trouser/skirt size, models with BMI change were additionally adjusted for BMI at ahe 20, models with trouser/skirt size were additionally adjusted for BMI, and models with height were additionally adjusted for body weight.†methylation index including the five CIMP markers (CACNA1G, IGF2, NEUROG1, RUNX3, and SOCS1), MLH1, and the APC gene.‡Based on baseline non-occupational physical activity for women (low≤30 minutes/day, intermediate = 30–90 minutes/day, high≥90 minutes/day) and occupational physical activity at the longest held job for men (low≤8 kj/minute, intermediate = 8–12 kj/minute, and high≥12 kj/minute).