METAPLASTIC CARCINOMA BREAST: A CASE SERIES

Introduction: Metaplastic breast carcinoma is a distinct histological type of breast cancer and comprises of two components ofboth epithelial & mesenchymal type in a single tumor. It includes adenosquamous, squamous cell carcinoma (SCC), spindle cell carcinoma, metaplastic carcinoma with mesenchymal differentiation, mixed carcinoma and myoepithelial carcinoma.

Materials and Methods: The study comprises of 5 cases of Metaplastic Breast carcinoma and was conducted in the Department of Pathology in Western part of India.

Discussion: MBC is characterized by adenocarcinoma admixed with spindle cells, squamous cells and mesenchymal differentiation. Among the five cases in the present series, two cases showed lymph nodes metastasis. Commonlyimmunohistochemistry (IHC) markers in cases of MBC shows triple negative for estrogen receptor (ER), progesterone receptor (PR) and HER2-neu.

Conclusion: The MBC has a poor prognosis and have a diverse clinical behavior, variable histology and different regime of treatment.