In the cell, stalled ribosomes are rescued through ribosome-associated protein quality-control (RQC) pathways. We demonstrate that RqcH is responsible for tRNAAla selection during RQC elongation, wher
Proteins that misfold in the endoplasmic reticulum (ER) are transported back to the cytosol for ER-associated degradation (ERAD). The Sec61 channel is one of the candidates for the retrograde transpor
Misfolded proteins in the endoplasmic reticulum (ER) are degraded by ER-associated degradation (ERAD). While ERAD components involved in degradation of luminal substrates are well-characterized, much
Structural coordinates, cryo-EM maps, and PDB validation reports for the OS9-SEL1L-HRD1 ERAD core complex. Maps were filtered to 4A for visualization. Half-maps have also been provided.
