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Effects of PRIMA-1 treatment on Saos-2 p53-null and Saos-2 p53-His273 cells

ChEBI2009-04-15 更新2026-07-21 收录

p53靶向治疗

骨肉瘤细胞实验

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-15658 数据链接链接失效反馈

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资源简介：

Effects of PRIMA-1 treatment on Saos-2 p53-null and Saos-2 p53-His273 cells

应用场景：

创建时间：

2009-04-15

p53靶向治疗

肿瘤药物协同治疗

Targeting the Mdm2 oncoprotein by drugs has the potential of re-establishing p53 function and tumor suppression. However, Mdm2-antagonizing drug candidates, e. g. Nutlin-3a, often fail to abolish canc

NIAID Data Ecosystem60

AcGlcAs: A Novel P53-Targeting Arsenical with Potent Cellular Uptake and Cancer Cell Selectivity

p53靶向治疗

抗癌药物开发

Arsenic trioxide (ATO) targets PML/RARα and leads to miraculous success in treating acute promyelocytic leukemia. Notably, ATO also targets p53, the most frequently mutated protein in cancers, through

NIAID Data Ecosystem50

Supplementary Table from Decreased DNA Damage and Improved p53 Specificity of RITA Analogs

抗肿瘤药物优化

p53靶向治疗

Supplementary Table from Decreased DNA Damage and Improved p53 Specificity of RITA Analogs

NIAID Data Ecosystem40

Transcriptional profiling of lung tumour cell lines with distinct p53 mutations in the absence or presence of WT p53

癌症分子机制

p53靶向治疗

Microarray expression data generated to determine the impact of defined p53 mutations on lung cancer cell phenotypes, and on the tumour supressive responses induced by WT p53 restoration. In murine mo

NIAID Data Ecosystem60

LIN28B inhibition sensitizes cells to p53-restoring PPI therapy through unleashed translational suppression

p53靶向治疗

翻译调控机制

supplementary data table

Figshare2022-07-03 更新40