Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels

The transmission of heartbeat through the cerebral vascular system is known to cause intracranial pressure pulsations. Here we report that arterial pressure pulsations can directly modulate central neuronal activity. In a semi-intact rat brain preparation, vascular pressure pulsations elicit correlated local field oscillations in the olfactory bulb (OB) mitral cell layer. These oscillations do not require synaptic transmission, but reflect baroreceptive transduction in mitral cells. This transduction is mediated by an excitatory mechanosensitive ion channel and modulates neuronal spiking activity. Indeed, in awake animals, the heartbeat entrains the activity of a subset of OB neurons within ~20 ms. Thus, we propose that this fast intrinsic interoceptive mechanism can modulate perception, e.g. during arousal, within the OB and also possibly across various brain areas., See Methods section of associated manuscript., , # Data from: Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels

The dataset consists of tables that list (1) all the data points displayed in cumulative graphs in figures; these are the results of analyses such as the power of local field potential oscillations across different experimental conditions (2) the original data traces and their fast Fourier transforms (if applicable) shown in figure panels with exemplary recordings. These are either local field potential recordings over time from the phrenic nerve and the olfactory bulb brain tissue in our semi-intact preparation of juvenile rats, and/or recordings of pressure over time at the cannula (see Fig. 1A). In addition, for Fig. 7 and Fig. S6, there are matlab files provided that contain the time stamps for heartbeats, inspiration and neuronal spiking activity from in vivo extracellular recordings of spiking activity in adult head fixed mice.

## Description of the data and file structu...