Identification of structural variants in patients with Acute Myeloid Leukemia and normal karyotype by Nanopore sequencing

In this study, we exploited the long-reads Oxford Nanopore Sequencing technology to explore the genome of a cohort of 152 AML patient with normal cytogenetics, aiming to address the genomic analysis challenges and to identify new potential genomic biomarkers able to refine the prognostic forecasting for normal karyotype AML patients.