Divergence map of CRISPR fitness co-dependency and Perturb-seq transcriptional coupling across 26.2M human gene pairs

This resource is a divergence map comparing two widely used signals of gene-gene functional coupling derived from public perturbation data. The first is CRISPR knockout-fitness co-dependency from DepMap and transcriptional-response coupling from genome-scale Perturb-seq and Replogle et al. Across 7,244 shared genes, the two signals are nearly independent, while both recover known protein complexes, and transcriptional coupling shows stronger enrichment for curated sythetic-lethal pairs than fitness co-dependency under dependence-aware inference. The map scores every gene pair on both signals and ranks them by disagreement, annoated with synthetic-lethality and shared-pathway status. It accompanies the manuscript "Transcriptional Coupling Shows Stronger Synthetic-Lethality Enrichment Than CRISPR Fitness Co-Dependency Across Two Public Perturbation Datasets" and includes the analysis code, random seeds, source-data versions, and scripts reproducing all figures and tables.