Collectively, these findings establish the existence of a brain-encoded inflammatory engram that governs the persistence and relapse of IC and highlight neuromodulation of engram circuits as a potenti

Figshare2026-03-20 更新30

DataSheet1_P2X7 Receptor Blockade Protects Against Acrolein-Induced Bladder Damage: A Potential New Therapeutic Approach for the Treatment of Bladder Inflammatory Diseases.PDF

膀胱炎症模型

P2X7受体拮抗剂

Inflammatory conditions of the urinary bladder have been shown to be associated with urothelial damage and loss of function. The purinergic P2X7 receptor has been implicated in several inflammatory co

NIAID Data Ecosystem10

LL-37 instillation leads to local and systemic inflammatory changes and GM-0111 reduces the inflammatory effects of LL-37.

膀胱炎症模型

抗炎药物评估

The animals treated with LL-37 show decreased body weight gain (A), increased bladder weight (B), gross anatomical changes in the bladder (C), severity of inflammatory changes in histological observat

NIAID Data Ecosystem40

Bladder response to a single sub-noxious dose of intravesical LPS.

膀胱炎症模型

肾脏生理学

Bladder response to a single sub-noxious dose of intravesical LPS.

NIAID Data Ecosystem10