Elucidating new mechanisms controlling the responses induced by the innate immune receptor Stimulator of Interferon Genes (STING)

The immune receptor STING is crucial for detecting microbial infections and mounting an immune response via the production of inflammatory mediators. However, inappropriate STING activation is linked to several diseases including, autoimmune and neuroinflammatory conditions. This thesis better defines several new key aspects of STING responses, including a clearer understanding of the molecular mechanisms controlling inflammation, as well as how STING responses are shut off to prevent chronic inflammation. Understanding STING function is important for effective targeting of this pathway for disease prevention.