Aerosol uptake and biomarkers of exposure - contrast

This dataset was generated in an in vivo OECD TG 413 90-days nose-only inhalation study where Sprague-Dawley rats were exposed to either 3R4F cigarette smoke or aerosols of the carbon heated tobacco product (CHTP) 1.2, a heat-not-burn platform. The study contains additional test groups that were examined following a systems toxicology approach (please refer to the study page for more detail on the study design). Biomarkers of exposure, including respiratory physiology, markers of exposure in blood, in plasma and urine and markers of stress in serum were measured. This dataset contains the statistics resulting from the comparison of treatment and control groups.