Development of Cognitive and Imaging Biomarkers Predicting Risk of Self-Blaming Bias and Recurrence in Major Depression

This data-set consists of fully anonymised task-based fMRI
using a value-related moral sentiments task which probes emotions related to
self-blame such as guilt and blaming others, such as anger, structural 3
dimensional T1 weighted and resting-state fMRI data for remitted MDD and
Healthy Control participants taking part in our studies. Data sharing is
stipulated by our MRC-approved data management plan. Basic anonymised clinical
and demographic descriptors are also available.

In addition to the anonymised clinical data, the dataset
also includes anonymised results of standard questionnaires, phenomenological
psychopathology and neurocognitive tasks probing moral sentiments, emotional
memory, action tendencies, and social knowledge which were described in our
papers, alongside some unpublished data which can be used after seeking
permission from the chief investigator.
Data from the following publications
are entailed in the dataset which should be cited when using the different
aspects of the data (links to all are provided in the REFERENCES section):

-Gethin
J.A., Lythe K.E., Workman C.I., Mayes A., Moll J., Zahn R. Early life stress
explains reduced positive memory biases in remitted depression. Eur
Psychiatry (2017) 45:59-64: Early life
event classification and emotional recognition memory test

-Workman
C.I., Lythe K.E., McKie S., Moll J., Gethin J.A., Deakin J.F.W., Elliott R.,
Zahn R. A novel resting-state functional MRI signature of resilience to
recurrent depression. Psychological Medicine (2017) 47: 597–607: Resting
state fMRI data with prospective clinical follow-up of remitted MDD
participants over 14 months

-Workman
C.I., Lythe K.E., McKie S., Moll J., Gethin J.A., Deakin J.F.W., Elliott R.,
Zahn R. Subgenual cingulate-amygdala functional disconnection and
vulnerability to melancholic depression. Neuropsychopharmacology (2016) doi:
10.1038/npp.2016.8: Resting state fMRI cross-sectional MDD vs Healthy Control
comparisons

-Lythe
K.E., Moll J., Gethin J.A., Workman C.I., Green S., Lambon Ralph M.A., Deakin
J.F., Zahn R. Self-blame-selective hyperconnectivity between anterior
temporal and subgenual cortices and prediction of recurrent depressive
episodes. JAMA Psychiatry (2015): doi:10.1001/jamapsychiatry.2015.1813:
Prospective fMRI data for prediction of 14 months clinical follow-up in
remitted MDD (Karen Lythe Sample)

-Zahn
R., Lythe K.E., Green S., Gethin J.A., Deakin J.F., Young A.H., Moll J. The
role of self-blame and worthlessness in the psychopathology of major
depressive disorder. Journal of Affective Disorders (2015) DOI: http://dx.doi.org/10.1016/j.jad.2015.08.001: Psychopathological
assessment (AMDP) and moral emotion addendum

-Zahn
R., Lythe K.E., Gethin J.A., Green S., Deakin J.F., Workman C., Moll J.
Negative emotions towards others are diminished in remitted major depression.
European Psychiatry (2015) doi: 10.1016/j.eurpsy.2015.02.005:
VMST=MST(value-related moral sentiment task)

-Green
S., Lambon Ralph M., Moll J., Zakrzewski J., Deakin J.F.W., Grafman J., Zahn
R. The neural basis of conceptual-emotional integration and its role in major
depressive disorder. Social Neuroscience (2013) 8(5): 417-433: CSKD:
conceptual social knowledge differentiation task – unpublished additional
data included in dataset

-Green
S., Moll J., Deakin J.F.W., Hulleman J., Zahn R. Proneness to decreased
negative emotions in major depressive disorder when blaming others rather
than oneself. Psychopathology (2013) 46(1): 34-44: VMST=MST(value-related
moral sentiment task)

-Green
S., Lambon Ralph M., Moll J., Deakin J.F.W., Zahn R. Guilt-selective
functional disconnection of anterior temporal and subgenual cortices in major
depressive disorder. Archives of General Psychiatry (2012) 69(10): 1014-1021:
cross-sectional fMRI (Sophie Green sample)

-Duan
S., Lawrence A., Valmaggia L., Moll J., Zahn R. The role of blame-related
action tendencies

in the vulnerability to major depressive disorder. MedRxiv 2020: https://doi.org/10.1101/2020.11.15.20232058: Action tendencies task
(action)

-Lythe
KE, Gethin JA, Workman CI, Lambon Ralph MA, Deakin JFW, Moll J, et al.
Subgenual activation and the finger of blame: individual differences and
depression vulnerability. Psychol Med 2020: 1-9: Description of autonomy and
sociotropy dimensions of self-blame and its association with fMRI results.