Radial organization of spheroids.

Combination of images of a cross-section of a tumor simulated with the model presented in this article depicting the spatial organization of cellular phenotypes (proliferating, dying) and the molecular agents considered by the proposed model as main resources (oxygen, glucose), growth/viability promotors (GP/VP) or growth/viability inhibitors (GI/VI). The arrows point into the direction from high to low concentrations. The image shall be compared with the corresponding scheme in ref. [8], which shows a combination of images of spheroid median sections studied with different technologies: autoradiography, TUNEL assay, bioluminescence imaging, and probing with oxygen micro-electrodes.