VNN1

This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24. [provided by RefSeq, Feb 2009]

本基因编码范宁蛋白家族的成员，该家族成员间具有广泛的序列相似性，亦与生物素酶具有相似性。该家族包括分泌型和膜结合型蛋白，其中少数报道参与造血细胞的迁移过程。然而，尚未在范宁蛋白中发现生物素酶活性，但它们具有泛戊二酸酶活性，这可能在氧化应激反应中发挥作用。此蛋白与其小鼠同源蛋白类似，可能是一种GPI锚定的细胞表面分子。小鼠蛋白由血管周围胸腺基质细胞表达，并调节T细胞祖细胞的胸腺迁移。此基因位于染色体6q23-q24处，与另外两个范宁基因紧密相邻，且转录方向一致。[由RefSeq提供，2009年2月]