Lipinski's rule-of-five drug-likeness properties of potential ICL inhibitors.

Abbreviations: Mi LogP (hydrophobicity measurement: octanol/water partition coefficient); TPSA (topological polar surface area); n atoms (number of atoms); MW (molecular weight); n ON (hydrogen bond acceptor); n OHNH (number of hydrogen bond donor); n violations (number of Lipinski's rule-of-five violations); n rotb (number of rotatable bonds); MV (molecular volume).High bioavailability are more probable for a compound when there are ≤5 hydrogen bond donors, ≤10 hydrogen bond acceptors, molecular weight ≤500, and Mi LogP ≤5; violation more than one of these rules may have problem with bioavailability [26].