L0 (expressed as n ⋅ Kd and n ⋅ Kd′) for a set of hypothetical hERG blockers resulting in the pro-arrhythmic fractional channel occupancy levels predicted from our AP simulations.
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https://figshare.com/articles/dataset/_i_L_i_sub_0_sub_expressed_as_i_n_i_i_K_i_sub_i_d_i_sub_and_i_n_i_i_K_i_sub_i_d_i_sub_for_a_set_of_hypothetical_hERG_blockers_resulting_in_the_pro-arrhythmic_fractional_channel_occupancy_levels_predicted_from_our_AP_simulations_/7286891
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Blocker Kd = 5 μM in all cases, where kon ranges between 1x104 and 1x109 M-1 s-1 and koff between 0.005 and 5,000 (noting that the pro-arrhythmic occupancy level increases as koff speeds). n ⋅ Kd was back-calculated from the predicted pro-arrhythmic occupancy using Eq 19.
创建时间：
2018-11-01
