The transcriptional network of wild type ERG and ERG mutant at K362. Homo sapiens

We have identified a specific site in the ERG protein that undergoes post-transcriptional modification. We have mutated this site and generated stably expressing LNCaP cell lines. In this study we evaluated the transcriptional profile induced by ERG in LNCaP stably expressing ERG wild type , ERG mutant or empty vector (EV). Overall design: Two replicates for each condition are considered (2 control cell lines, two cell lines with wild type ERG overexpression and two cell lines with mutant ERG overexpression).