The Pathogen-Host Interactions Database, version 4.17

PHI-base is an online database (available at phi-base.org) that catalogues experimentally verified pathogenicity, virulence and effector genes from fungal, oomycete and bacterial pathogens, which infect animal, plant, fungal and insect hosts. PHI-base is a valuable resource in the discovery of genes in medically and agronomically important pathogens, which may be potential targets for chemical intervention.

Each entry in PHI-base is curated by domain experts and is supported by strong experimental evidence (for example, gene disruption and gene complementation experiments), as well as literature references in which the original experiments are described. Each gene in PHI-base is presented with its nucleotide sequence and deduced amino acid sequence (available in a FASTA file), as well as a detailed description of the predicted protein's function during the host infection process. To facilitate data interoperability, we have annotated genes using ontologies, controlled vocabularies, and links to external sources (including UniProt, Gene Ontology, Enzyme Commission, NCBI Taxonomy, EMBL, PubMed and FRAC).

This PHI-base dataset is a Frictionless Data Package that contains an export of the PHI-base database in CSV format (comma-separated values), plus a FASTA file with sequences for each gene in the database. This version of the dataset, version 4.17, contains 5,521 publications, covering 22,408 pathogen–host interactions and 9,973 pathogen genes across 296 pathogen species and 249 host species.

Erratum

Please note that the funding information included in the readme file for this dataset (specifically README.md and README.html) is incorrect. The correct funding sources are Growing Health [BB/X010953/1; BBS/E/RH/230003A] and Delivering Sustainable Wheat [BB/X011003/1; BBS/E/RH/230001B], both ultimately funded by the Biotechnology and Biological Sciences Research Council (BBSRC). The metadata for this dataset has been amended to use the correct funding sources (updated 16 September 2024).