Variation and positive selection measures of sites at the primate APN/HCoV-229E binding interface.

The 10 sites in the APN receptor that are involved in binding the HCoV-229E spike protein are shown. For each site, measures of normalized evolutionary rate by Rate4Site [20], amino acid variation using Shannon entropy [21], branch-scaled dN-dS from SLAC [22], and likelihood ratio test (LRT) from MEME [23] are included. Site 292 dN-dS and LRT values required the removal of one species from the alignment that contains a gap at this site.
(XLSX)