Cerebrovascular Dysregulation in Chronic Kidney Disease Training Data

This data is associated with the following clinical trial testing the effects of execise training on cerebral autoregulation in chronic kidney disease (NCT 05571605)

Objective: To evaluate the effects of 12-weeks of aerobic exercise training vs stretching (control group) on dynamic cerebral autoregulation in participants with chronic kidney disease (CKD) stages III-IV.

Design: This study was a randomized controlled trial. Participants with CKD stages III-IV were enrolled for participation. All participants underwent a baseline assessment of Mean arterial pressure-Middle cerebral artery blood velocity very low frequency phase (radians) and gain (cm/s/mmHg). Participants were then randomized to a 12-week training intervention consisting of either aerobic exercise training or stretching (active control). The assessment of dynamic cerebral autoregulation was then repeated following the intervention.

Methods: Mean arterial pressure-Middle cerebral artery blood velocity very low frequency phase (radians) and gain (cm/s/mmHg) were measured during repeated bouts of sit to stand at 0.05Hz. Mean arterial pressure was measured via finger photoplethysmography. Middle cerebral artery blood velocity was measured via transcranial Doppler ultrasound. A transfer function analysis was performed to derive mean arterial pressure-middle cerebral artery blood velocity very low frequency phase (radians) and gain (cm/s/mmHg).