The epigenetic Kit modification is maintained in the <i>Dnmt2 <sup>−/−</sup></i> progeny of heterozygote parents but not further transmitted.
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Analysis of 3 litters for each cross. In crosses #1 and 2, Kit genotypes are indicated in the Dnmt2 −/− fraction of the progeny. In cross #3, the male parent was a Dnmt2 −/− homozygote with a modified Kit allele born from cross #2. When mated with a wild type female, only non-modified Kit+ alleles were transmitted to the progeny.
创建时间：
2013-05-23
