Cargo Recognition And Sorting
收藏reactome.org2025-03-24 收录
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Initiation/Cargo Recognition is mediated by ESCRT-0, a heterodimer consisting of Vps27 and Hse1. ESCRT-0 binds Phosphatidyl inositol 3- phosphate (PI3P) on endosomes via a FVYE domain and ubiquitinated cargo via two UIM domains.
启动/货物识别过程由ESCRT-0介导,ESCRT-0为由Vps27和Hse1组成的异源二聚体。ESCRT-0通过FVYE结构域与内体上的磷脂酰肌醇3-磷酸(PI3P)结合,并通过两个UIM结构域与泛素化的货物结合。
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