NRLiSt

The NRLiSt BDB (Nuclear Receptors Ligands and Structures Benchmarking DataBase) is a non-commercial manually curated benchmarking database dedicated to the Nuclear Receptor(NR) ligands and structures pharmacological profiles. The NRs formed a superfamily of related transcription factors composed of 48 members, divided into seven subfamily (NR0 to NR6). The NRs are involved in a wide range of physiological key functions: growth, differentiation, reproduction, metabolism, electrolytic homeostasis, stress response and immune function... Several commercially-available compounds acting through the activation (agonist) or inhibition (antagonist) of one (or several) NR(s) are currently used.NRLiSt BDB（核受体配体与结构评测数据库，Nuclear Receptors Ligands and Structures Benchmarking DataBase）是一款非商业性的人工整理评测数据库，专门面向核受体(Nuclear Receptor, NR)配体及其结构的药理学特征构建。核受体是一类具有亲缘关系的转录因子超家族，共包含48个成员，可划分为7个亚家族（NR0至NR6）。核受体参与诸多关键生理过程，涵盖生长、分化、生殖、代谢、电解质稳态、应激反应与免疫功能等多个领域。目前已有多款通过作为激动剂（agonist）激活或作为拮抗剂（antagonist）抑制单个或多个核受体发挥作用的商用化合物投入应用。

搜集汇总

背景与挑战

背景概述

NRLiSt BDB是一个非商业手动管理的基准数据库，专注于核受体的配体和结构药理学分析。它包含48个核受体成员的数据，提供配体与结构信息用于虚拟筛选。