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A stem cell model identifies two alternative cell fates in CBFA2T3::GLIS2-driven acute megakaryoblastic leukemia initiation

NIAID Data Ecosystem2026-05-02 收录

急性巨核细胞白血病

细胞疾病模型

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE277004 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2025-08-28

功能基因组学

细胞疾病模型

Clonal cellular variance often confounds reproducibility of forward and reverse genetic studies. We developed combinatorial approaches for whole genome saturated mutagenesis using haploid murine ES ce

NIAID Data Ecosystem70

FGF21 treatment and iPSC-derived neurons

精神药物机制

细胞疾病模型

FGF21 analogs tested in clinical trials in metabolic diseases i.e. type 2 diabetes mellitus and non-alcoholic fatty liver disease are generally well-tolerated. FGF21 is a peptide hormone that is prima

NIAID Data Ecosystem50

Cellular and axonal transport phenotypes due to the C9ORF72 HRE in iPSC motor and sensory neurons. Cellular and axonal transport phenotypes due to the C9ORF72 HRE in iPSC motor and sensory neurons

神经退行性机制

细胞疾病模型

Transcriptomic signature of the C9orf72 hexonucleotide repeat expansion in induced pluripotent stem cell derived motor and sensory neurons. Overall design: iPSC-MNs for RNA sequencing were harvested o

NIAID Data Ecosystem30

iPSC-derived cardiomyocyotes reveal abnormal TGFÃ signaling in left ventricular non-compaction cardiomyopathy

抗病分子机制

细胞疾病模型

Left ventricular non-compaction (LVNC) is the third most prevalent cardiomyopathy in children and its pathogenesis has been associated with the developmental defect of the embryonic myocardium. We sho

NIAID Data Ecosystem60

Isogenic human pluripotent stem cell disease models reveal actin binding Rho activating protein deficiency underlies the cardiac troponin T DK210 mutation-induced familial dilated cardiomyopathy II

心肌病机制研究

细胞疾病模型

Different single mutations on the same sarcomeric gene often cause distinct cardiomyopathy phenotypes as dilated (DCM) or hypertrophic cardiomyopathy (HCM). The key factors involved in this disease di

NIAID Data Ecosystem30

A stem cell model identifies two alternative cell fates in CBFA2T3::GLIS2-driven acute megakaryoblastic leukemia initiation

资源简介：

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