HNF4A intestinal epithelial conditional loss incidence on jejunum expression from mice fed a HFD.

HNF4A encodes a nuclear receptor required for the development of the intestine and involved in the homeostasis maintenance of intestinal epithelial cells during the adulthood. Also strongly related to the hepatic lipid metabolism, little was known about its metabolic relevance from the intestine when challenged by a high fat diet. We used microarrays to detail the global programme of jejunal gene expression depending on HNF4α and influenced by HFD. Adult mice conditionally deleted for HNF4α from intestinal epithelial cells and control mice were fed a high fat diet for 12 weeks.