Genetic Variation in Essential Laboratory Primates Rhesus Macaque (Macaca mulatta)

HGSC has sequenced both deep (~30X) and shallow (~6X) whole genomes on 198 animals from 8 National Primate Research Centers (NPRCs) and primate research facilities. There are an additional 50 whole exomes that have been sequenced from each of five NPRCs. All of these animals are Macaca mulatta. All sequencing was done on Illumina HiSeq machines. Analysis will pursue characterization of genomic variation between individuals and subspecies (Indian and Chinese).

HGSC对来自8个国家灵长类研究中心（National Primate Research Centers，缩写为NPRCs）及相关灵长类研究机构的198只恒河猴（Macaca mulatta）开展了深度（约30X）与浅度（约6X）全基因组测序。另有来自5个国家灵长类研究中心的各50份全外显子组测序样本。所有受试动物均为恒河猴。本次测序工作全部依托Illumina HiSeq测序平台完成。本数据集的后续分析将旨在解析个体间及亚种（印度亚种与中国亚种）间的基因组变异特征。

搜集汇总

背景与挑战

背景概述

该数据集聚焦于恒河猴（Macaca mulatta）的遗传变异分析，由贝勒医学院人类基因组测序中心通过全基因组和全外显子组测序方法构建，旨在创建全面的遗传变异目录（包括单核苷酸变异、插入缺失、拷贝数变异等），并识别与人类健康和疾病相关的功能变异。数据集包含889个样本和982个测序运行，于2014年更新，适用于模式生物研究。