Figure 5 Raw data
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Figure 5. siRNA-mediated suppression of CRTAM, FOXP4, GRIN2C, LILRA3, PIBF1, SCGB3A1 and TXNDC12 in SH-SY5Y human neuroblastoma cells reduces inflammation-induced pS199/pS202 (AT8) and/or pT231 (AT180) tau phosphorylation. SH-SY5Y cells were
transiently transfected with siRNAs (individually, in triplicate for the GOI).
After 48 h, cells were treated with CM (at 50%) derived from BV2 microglial
cells. After 24 h, the lysates from SH-SY5Y cells were prepared and Western
blot was performed for AT8 and AT180 antibodies and actin as loading control. Note
that the levels of AT8 and/or AT180 are significantly altered in SH-SY5Y cells
upon knockdown of MPxgb(AD) predicted CRTAM,
FOXP4, GRIN2C, LILRA3, PIBF1, SCGB3A1 and TXNDC12 genes. Data shown are mean + s.e.m;
unpaired t tests; *p<0.05; **p<0.01, ***p<0.005, n=3
technical replicates and n=3 biological replicates).
创建时间：
2021-12-14
