Transcriptomic analysis of D458 medulloblastoma cells treated with 10nM THZ1 or DMSO in comparison to shNull and shCDK7-1,-2,-3 genetic knockdown cell lines
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE164933
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The goal of this study was to first determine the effect of CDK7 chemical inhibition (THZ1) on global gene expression. Then to observe and compare to the transcriptomic profile of CDK7 genetic knockdown in D458 medulloblastoma cells. RNA-seq was performed using the illumina HiSEQ 4000 HT for 1x50 sequencing. High quality base calls at 95% ≥ Q30 were obtained with 53M-69M single reads. Statistical analysis of count data was performed with DESeq2 R package.
创建时间:
2021-07-01



