Genome and plasmid sequences of C. trachomatis strain IU888 previously identified as being resistant to tetracycline.. Chlamydia trachomatis IU888

Two C. trachomatis isolates from cases of repeated treatment failure were previously characterised as being resistant to tetracycline. However, genome sequencing of these isolates did not reveal any known tetracycline-resistance genes or mutations that may confer resistance. Moreover, tetracycline resistance assays showed tetracycline sensitive phenotypes for both isolates. We therefore conclude that the previously findings can be explained by well-known difficulties in assaying C. trachomatis for antibiotic resistance.