SP1

The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

该基因编码的蛋白质是一种锌指转录因子，可结合众多启动子中的GC富集基序。编码的蛋白质参与多种细胞过程，包括细胞分化、细胞增殖、细胞凋亡、免疫反应、对DNA损伤的响应以及染色质重塑。蛋白质的翻译后修饰，如磷酸化、乙酰化、糖基化和蛋白酶解加工，显著影响该蛋白的活性，其可作为激活剂或抑制剂。针对该基因，已发现三种转录变体，分别编码不同的同源异构体。[由RefSeq提供，2014年11月]

搜集汇总

背景与挑战

背景概述

SP1数据集描述了该基因编码的锌指转录因子蛋白质，该蛋白质参与细胞分化、生长、凋亡等多种过程，并受多种翻译后修饰调控，存在三个不同的转录变体。