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The GTPase Rab39a matures phagosomes into MHC-I antigen-presenting compartments.

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https://www.omicsdi.org/dataset/pride/PXD016394
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We have found Rab39a to be important in dendritic cells to promote antigen crosspresentation. As Rab39a is a Rab GTPase, we sought to determine how it influenced the contents of phagosomes. Thus we used SILAC using Rab39a CRISPR KO or reconstituted cells to determine phagosomal protein differences using a proteomics based approach.
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2019-12-11
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