Transcription profiling of branching and non-branching regions of the mouse embryonic lung

During development, the proximal and distal regions of respiratory tract undergo distinct processes that ultimately give rise to conducting airways and alveoli. To gain insights into the genetic pathways differentially activated in these regions when branching morphogenesis is initiating, we characterized their transcriptional profiles in murine rudiments isolated at embryonic day 11.5.在机体发育过程中，呼吸道的近端与远端区域会经历截然不同的分化进程，最终分别形成传导气道与肺泡。为了探究分支形态发生（branching morphogenesis）启动阶段这两个区域内差异激活的遗传调控通路，我们对胚胎发育第11.5天分离得到的小鼠呼吸道原基的转录谱（transcriptional profiles）进行了系统性表征。