miR-34 regulates JARID1A expresion (NB1691). Homo sapiens

p53 inactivation occurs only rarely in neuroblastoma, although miR-34, a transcriptional target of p53, is often deleted in neuroblastoma, suggesting another way in which p53 signaling might be impaired. In this study we show that miR-34 directly targets and downregulates the Polycomb Repressive Complex 2 (PRC2) and its associated histone demethylase, JARID1A, in a p53-dependent manner, Overall design: 8 samples were transfected with siRNA control or JMJD2B, MYCN, JARID1A into NB1691 cells.