Genome-wide RNA expression analysis of rat dorsal root ganglion tissue after local absorbable collagen sponge implantation and BMP-2 exposure

Analysis of whole dorsal root ganglion tissue expression signatures in responses to absorbable collagen sponge implantation with and without BMP-2 exposure. The hypothesis is that inflammatory macrophage-associated responses to ACS implantation contributes to nociception in the DRG and spinal nerve.本研究针对植入含与不含骨形态发生蛋白2（bone morphogenetic protein-2, BMP-2）的可吸收胶原海绵（absorbable collagen sponge, ACS）后，背根神经节（dorsal root ganglion, DRG）全组织的表达谱展开分析。本研究的核心假设为：植入ACS所引发的炎症性巨噬细胞相关应答，会促成背根神经节与脊神经的伤害性感受。