A gene expression signature classifying telomerase and ALT immortalisation reveals an hTERT regulatory network and suggests a mesenchymal stem cell origin for ALT Telomere length is maintained by 2 kn
It has been shown previously that some immortalized human cells maintain their telomeres in the absence of significant levels of telomerase activity by a mechanism referred to as alternative lengtheni
In most human cancers, telomere is elongated by telomerase which contains reverse transcriptase TERT and the RNA template TERC. The mature TERC is non-polyadenylated while the oligo(A)-containing prec
