Expression data of sciatic nerves from mice with Schwann-cell specific Sip1 deletion compared to control mice

Schwann cell maturation is tightly controlled by a set of transcriptional regulators. We have deleted the zinc-finger transcription factor Sip1 specifically from immature Schwann cells and observed a dramatic developmental delay. In an attempt to define the developmental stage of Sip1-deficient Schwann cells, we performed microarray analysis of Schwann cell-specific mutants compared to controls at the age of 25 days (P25). Sciatic nerves of 3 mutant mice and 3 corresponding controls were isolated at the age of 25 days.施万细胞（Schwann cell）的成熟过程受到一系列转录调控因子的严格调控。我们特异地在未成熟施万细胞中敲除了锌指转录因子Sip1，并观察到显著的发育迟缓。为明确Sip1缺失施万细胞的发育阶段，我们于出生后第25天（P25）对施万细胞特异性敲除突变体与对照组样本开展了基因芯片分析。本次实验中，我们于该时间点分离获取了3只突变小鼠与3只对应对照组小鼠的坐骨神经。