HCV NS3 protease domain with P1-P3 macrocyclic ketoamide inhibitor
收藏Protein Data Bank Japan2024-04-03 更新2026-03-21 收录
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https://pdbj.org/mine/summary/3knx
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HCV NS3 protease domain with P1-P3 macrocyclic ketoamide inhibitor Descriptor: (2R)-2-{(3S,13S,16aS,17aR,17bS)-13-[({(1S)-1-[(4,4-dimethyl-2,6-dioxopiperidin-1-yl)methyl]-2,2-dimethylpropyl}carbamoyl)amino]-17,17-dimethyl-1,14-dioxooctadecahydro-2H-cyclopropa[3,4]pyrrolo[1,2-a][1,4]diazacyclohexadecin-3-yl}-2-hydroxy-N-prop-2-en-1-ylethanamide, BETA-MERCAPTOETHANOL, HCV NS3 Protease, ... Authors: Venkatraman, S, Velazquez, F, Wu, W, Blackman, M, Chen, K.X, Bogen, S, Nair, L, Tong, X, Chase, R, Hart, A, Agrawal, S, Pichardo, J, Prongay, A, Cheng, K.-C, Girijavallabhan, V, Piwinski, J, Shih, N.-Y, Njoroge, F.G. Deposit date: 2009-11-12 Release date: 2010-10-27 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Discovery and structure-activity relationship of P1-P3 ketoamide derived macrocyclic inhibitors of hepatitis C virus NS3 protease. J.Med.Chem., 52, 2009
创建时间：
2009-11-12
