Relation between quality of life and single nucleotide polymorphisms (n = 174,598).

Note: In total 174,574 SNPs were available on the imputed iCOGS chip. Bonferroni p-value = 0.05/174,598 = 2.86E-07. For the continuous variables (i.e. global health/quality of life; emotional functioning; and cognitive functioning) linear regressions were performed. For the dichotomized variables (i.e. physical functioning; role functioning; and social functioning) we used logistic regression analyses. Chr = chromosome; Position = position of the chromosome; Minor/major = minor and major alleles based on forward strand and minor allele frequencies in Europeans; MAF = minor allele frequency over all European controls in iCOGS; Beta = beta value for the minor allele relative to the major allele; SE = standard error; p = p-value.a = cognitive functioning was transformed by using square root transformation [√(101-raw score)] ranging from 1–10, with low scores having a better cognitive functioning, therefore the direction of the relation is reversed.Ɨ = the gene to which this SNP belongs is unknown, the closest gene is reported.Relation between quality of life and single nucleotide polymorphisms (n = 174,598).