Targeting intermolecular interactions to reduce viscosity in monoclonal antibody formulations: Viscosity-reducing additives analysis

The table is the supporting information for a review journal article describing literature about additives that reduce the viscosity of monoclonal antibody (mAb) formulations. The table includes compound names, chemical descriptors of these compounds (SlogP, TPSA (total polar surface area), Average molecular weight, Number of Rotatable Bonds, Number of Hydrogen Bond Donors, Number of Hydrogen Bond Acceptors, Number of Hetero Atoms, Number of Aromatic Rings, Fraction of CSP3), the concentration of the compound that was used in the experiment and viscosity reduction [%]. The latter describes the percentage by which the viscosity of the mAb formulation was reduced when the compound was added relative to the viscosity of the formulation without the added compound. This data was used to find correlation between the molecular descriptors of the compounds and their viscosity-reducing effect as described in the journal article.