Circulating miR-499a-5p is a potential biomarker of MYH7-associated hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is the most common inherited myocardial disease with significant genetic and phenotypic heterogeneity. To search for novel biomarkers, which could increase the accuracy of HCM diagnosis and possibly improve understanding of its phenotype formation, we analyzed the levels of circulating microRNAs (miRNAs) − stable non-coding regulatory RNAs. Performed high throughput sequencing of miRNAs in plasma of HCM patients and controls pinpointed miR-499a-5p as one of 35 miRNAs dysregulated in HCM. We performed miRNA profiling in plasma of peripheral blood of 9 patients with hypertrophic cardiomyopathy (HCM) and 6 healthy controls (HC).