Supplementary Material for: Dupilumab for Chronic Spontaneous Urticaria with Comorbid Type 2 Inflammatory Conditions: Case Report and Systematic Review of the Literature

Abstract Introduction: Chronic spontaneous urticaria (CSU) is a heterogeneous, Th2-driven condition where standard therapies, including antihistamines and omalizumab, are often insufficient. Dupilumab, an IL-4Rα antagonist approved for several Th2-mediated diseases, has shown efficacy in CSU. Objective: To present a rare case of CSU coexisting with both asthma and eosinophilic gastroenteritis, successfully treated with dupilumab, highlighting the potential effectiveness and appropriateness of dupilumab in patients with multiple, simultaneous Th2-mediated comorbidities, and to perform a systematic review of the literature. Methods: A 32-year-old man with refractory CSU, asthma, and eosinophilic gastroenteritis was treated with dupilumab. A systematic literature search of PubMed and Embase was performed to identify any study types reporting treatment of CSU with dupilumab in patients with one or more coexisting Th2-mediated diseases. Results: The patient achieved complete remission of CSU, asthma, and eosinophilic gastroenteritis with dupilumab, with no reported side effects. The literature review identified eight studies comprising 25 CSU patients, most with coexisting atopic dermatitis or asthma. The majority achieved symptom control of urticaria as well as of the coexisting Th2 diseases, with only one report of mild side effects. Conclusions: Dupilumab is a suitable therapeutic option in patients with CSU and coexisting Th2-mediated conditions.