Data-driven criteria to assess fear remission and phenotypic variability of extinction in rats

Abstract:
Fear conditioning is widely employed to examine the mechanisms that underlie dysregulations of the fear system. Various manipulations are often used following fear acquisition to attenuate fear memories. In rodent studies, freezing is often the main output measure to quantify “fear”. Here, we developed data-driven criteria for defining a standard benchmark that indicates remission from conditioned fear and for identifying subgroups with differential treatment responses. These analyses will enable a better understanding of individual differences in treatment responding.

This data set includes all data and code used for the research publication, "Data-driven criteria to assess fear remission and phenotypic variability of extinction in rats", appearing in the journal <i>Philosophical Transactions B</i>.