NPAS4 binds FOS gene enhancer

Based on a study conducted using mouse cortical and hippocampal neurons as the model system, NPAS4 binds an enhancer element of the FOS gene (Kim et al. 2010; Ramamoorthi et al. 2011). In rat primary neurons, Npas4 and its heterodimerization partners Arnt and Arnt2 were shown to bind multiple sites in the Fos gene locus by high-throughput ChIP-seq (Brigidi et al. 2019). The heterodimers of NPAS4 with ARNT, ARNT2 and ARNTL are annotated as candidates for Fos gene binding.

基于采用小鼠皮层和海马神经元作为模型系统的研究，NPAS4结合FOS基因的增强子元件（Kim等，2010；Ramamoorthi等，2011）。在鼠原代神经元中，通过高通量ChIP-seq技术，发现Npas4及其异源二聚化伴侣Arnt和Arnt2结合Fos基因座上的多个位点（Brigidi等，2019）。NPAS4与ARNT、ARNT2和ARNTL形成的异源二聚体被标注为Fos基因结合的候选者。