Interaction between the TCF7L2 gene and dietary intake on metabolic syndrome risk factors among Saudi Arabian adults

Transcription factor-7-like 2 (TCF7L2) is the most critical type 2 diabetes (T2D) gene identified to date. The single-nucleotide polymorphism (SNP) rs7903146 in TCF7L2 in T2D interacts with dietary factors; however, research on nutrigenetics among Saudi Arabians is limited. This study investigated the interaction between the SNP rs7903146 and dietary intake on factors that may contribute to MetS among Saudi Arabian adults. This cross-sectional study included 271 adult participants (aged 20–55 years) of both genders. Anthropometric measurements and dietary assessments using a food frequency questionnaire were performed. Fasting blood samples were collected to analyze serum lipid, glucose, and insulin levels. Genetic analysis was performed using real-time polymerase chain reaction. Univariate regression was used to examine the association between the TCF7L2 SNP rs7903146 and laboratory parameters, and to test SNP-diet interactions. The additive model was used in the analysis and the T all..., , , # Interaction between the TCF7L2 gene and dietary intake on metabolic syndrome risk factors among Saudi Arabian adults

[https://doi.org/10.5061/dryad.6m905qgbg](https://doi.org/10.5061/dryad.6m905qgbg)

## Description of the data and file structure

A cross-sectional study was conducted with participants from Jeddah, Saudi Arabia, recruited between January 2023 and November 2023. The study sample included 274 adults (aged 20-55 years) of both genders with or without overweight or obesity according to body mass index (BMI ranged from 18-35 kg/m^2). Exclusion criteria included the presence of any diagnosed disease (such as both type 1 and 2 diabetes, CVD, hypertension, human immunodeficiency virus infection, liver disease, renal failure, cancer, or gastrointestinal disorder), use of medication that affected serum lipids or diabetic parameters, chemo or radiation therapy, surgery within the last 6 months, and women who were pregnant or lactating.

Study participants were recruited at the ...,